Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes.. See also. The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Nutrients. Author information: (1)Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, E-08028 Barcelona, Spain; CIBER … Cell Biol. Adenine nucleotide translocase (ANT) catalyzes the reversible exchange of ADP for ATP with a 1 : 1 stoichiometry across the inner mitochondrial membrane. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.
,This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. Adenine nucleotide translocator; Solute carrier family; References Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism. ANT2 was inhibited by transfecting cells with an ANT2-specific … Nucleotide transporters include the mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase or translocator (ANT), which imports ADP into the mitochondrial matrix, where it can be converted to ATP by ATP synthase, and exports the newly synthesized ATP to the cytosol, where it fuels the metabolic energy-requiring processes that are vital for cell survival [1, 2, 3, 4, 5]. Adenine nucleotide translocator; Solute carrier family; References
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) At 0.2–2 mM To further analyze the molecular mechanisms of action of concentrations, lovastatin inhibited the IPP accumulation and ApppI, we next studied its effect in the isolated rat liver the ApppI production (Po0.001) in a dose dependent manner … This is known as the 'taxonomic identifier' or 'taxid'.
,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism.
Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
Forlani et al. Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane protein involved in ATP/ADP exchange.
Rabbit anti Rat Adenine Nucleotide Translocator 1 antibody recognizes ADP/ATP translocase 1, also known as Adenine Nucleotide Translocator 1 (ANT1), ADP,ATP carrier protein 1 or Solute carrier family 25 member 4. adenine nucleotide translocase. Grancara S, Ohkubo S, Artico M, Ciccariello M, Manente S, Bragadin M, Toninello A, Agostinelli E. Amino Acids. (1999) J. has long been assumed that the ADP/ATP translocase is the only adenine nucleotide transporter in mitochon-dna. have the same checksum value, the likelihood that this would happen
Nothing is known, however, about the apoptotic activity of ANT3. ORF Names: XELAEV_18038881mg Imported. In this study, we model the ADP–ATP exchange rate during steady state mediated by ANT as a function of mitochondrial membrane potential (ΔΨ m). NIH Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant, apoptosis-inducing genes. Therefore it is the key link between ATP production in the mitochondrial matrix space Tested Reactivity: Human, Mouse, Rat. 439, 258–262]. Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported. PPIF - Wikipedia ROS increases uncoupling proteins (UCPs) and potentiate proton leakage through the adenine nucleotide translocator (ANT), the combination of which uncouples the mitochondria. (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase.
DNA Data Bank of Japan; a nucleotide sequence database, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations,
Information inferred from a combination of experimental and computational evidence, without manual validation.
using the generator polynomial: x64 + x4 + x3 + x + 1. 1998 Jan 23;422(1):36-42. doi: 10.1016/s0014-5793(97)01594-9. was revealed by studying some mutant forms of adenine nucleotide translocase, which causes aging-dependent cellu-lar degeneration. For that purpose the content of the adenine nucleotide translocase (ANT), the activity of adenine nucleotide translocation and the control of the ANT protein over State 3 respiration were estimated. The main difference between uniport, symport, and antiport is that uniport moves molecules across the membrane independent of other molecules, and symport moves two types of molecules in the same direction, but antiport moves two types of molecules in opposite directions. Ohkubo S, Mancinelli R, Miglietta S, Cona A, Angelini R, Canettieri G, Spandidos DA, Gaudio E, Agostinelli E. Int J Oncol. Toninello A, Dalla Via L, Testa S, Siliprandi D, Siliprandi N. Toninello A, Di Lisa F, Siliprandi D, Siliprandi N. Biochim Biophys Acta. 2020 Jan 11;12(1):197. doi: 10.3390/nu12010197. Although glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) are known as major proteins involved in the molecular mechanisms for accumulating 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) in cancer cells, sometimes, [18F] FDG accumulation cannot be explained by the expression of these two proteins. ,When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein. 618566 - adenine nucleotide translocase lysine methyltransferase; antkmt - family with sequence similarity 173, member a; fam173a;; chromosome 16 open reading frame 24; c16orf24 - antkmt Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. ApppI inhibits mitochondrial adenine nucleotide translocase (ANT) HMG-CoA reductase) and zoledronic acid. Validated: WB, ICC/IF, IHC. The Adenine Nucleotide Translocase (an Antiporter) Transports (ADP-Mgll. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))
,This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
,This section is used to point to information related to entries and found in data collections other than UniProtKB.
,This section provides general information on the entry.
,This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. 2016 Oct;48(10):2313-26. doi: 10.1007/s00726-016-2323-z. The current subsections and their content are listed below:
,This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
,The checksum is a form of redundancy check that is calculated Spermine, besides to be transported in mitochondria by an energy dependent electrophoretic mechanism, can be also released by two different mechanisms. Summary. The age-related elevation in ANT carbonyl content was correlated with a corresponding loss in its functional activity. These are stable identifiers and should be used to cite UniProtKB entries. HHS ese studies may provide new perspec-tives for the mechanism of mitochondrial degeneration, in. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Would you like email updates of new search results? Spermine binding to liver mitochondria deenergized by ruthenium red plus either FCCP or antimycin A. Bidirectional fluxes of spermine across the mitochondrial membrane. The recognition of two specific binding sites of the adenine nucleotide translocase by palmitoyl CoA in bovine heart mitochondria and submitochondrial particles. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. from the sequence. ▼ Cloning and Expression Willemen et al. Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis. Datasheet; SDS; References (5) Publishing research using ab109713? Gene names i: Name:slc25a5.L Imported. (Recall that these adenine nucleotides are negatively charged: ADP 3-and ATP 4-.) Phosphate translocase is also located in the inner mitochondrial membrane. Rabbit anti Rat Adenine Nucleotide Translocator 1 antibody recognizes ADP/ATP translocase 1, also known as Adenine Nucleotide Translocator 1 (ANT1), ADP,ATP carrier protein 1 or Solute carrier family 25 member 4. Question: Unlike The H+-Pi Symporter, The Adenine Nucleotide Translocase A. Adenine nucleotide translocases (ANTs) are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in cytosol. (2018) reported that the FAM173A gene encodes a 235-amino acid protein. Bcl-2 is a prosurvival factor that reportedly prevents the nonspecific permeabilization of mitochondrial membranes, yet enhances specific ADP/ATP exchange by these organelles. See also. ORF Names: XELAEV_18038881mg Imported. Here, we describe the characterization of adenine nucleotide translocase-1 (ANT-1), a central component of the permeability transition pore, which was identified using such a screen. This problem has … Datasheets and documents. The adenine nucleotide translocase, which extends across the inner membrane, binds ADP 3-on the outside (cytosolic) surface of the inner membrane and transports it inward in exchange for an ATP 4-molecule simultaneously transported outward (see Fig. 1985 May 28;815(3):399-404. doi: 10.1016/0005-2736(85)90366-9. The in vivo depression of adenine nucleotide translocation through the inner mitochondrial membrane was confirmed directly by measurements of [14 C]ADP translocase and 32 P i-ATP exchange reactions. Keywords: It is an antiporter. ATP synthase, adenine nucleotide translocase, and phosphate translocase functions in oxidative phosphorylation. 13-1 for the ionic forms of ATP and ADP). Therefore, I can offer a discount off a future purchase if you buy ab110322 now, test it in immunoprecipitation and submit feedback to us in the form of an Abreview. It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. Reactivity: Hu Species Glossary: Applications: ELISA, S-ELISA: Clone: 1D7. Synonyms: Ant1 Imported, slc25a5 Imported. The algorithm is described in the ISO 3309 standard. 439, 258–262]. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . This site needs JavaScript to work properly. Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis [Bauer et al. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.
, Automatic assertion according to sequence analysis,This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
,This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.
,This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.
,This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy. Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Adenine Nucleotide … Automatic assertion inferred from database entriesi, Automatic assertion inferred from database entriesi, Xenopus laevis and tropicalis biology and genomics resource, Automatic assertion according to sequence analysisi, Identification of Orthologs from Complete Genome Data, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. INTRODUCTION. The use of simulations and docking experiments revealed that Lys23 is a critical residue for controlling the affinity of ADP for ANT1, with the acetylated system having a much … Clipboard, Search History, and several other advanced features are temporarily unavailable. Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes.
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